Immunosuppressives in uveitis. A preliminary report of experience with chlorambucil.

Since the mid-I96os there has been a small but steady trickle of reports of patients with severe uveitis who have been treated with non-steroid immunosuppressive drugs. This has paralleled the use of these drugs in other non-malignant conditions. In the past 2 years 14 patients at the Institute of Ophthalmology have been treated with chlorambucil. This report is concerned with the preliminary findings in this group of patients. Chlorambucil was chosen for its relatively low toxic/therapeutic ratio, and its selective depression of lymphocytes (de Gruchy, 1970). The choice was encouraged by the experience of others who had used chlorambucil (Mamo and Azzam, 1970; Abdalla and Bahgat, I973).